Cerebrospinal Fluid β-Amyloid(1-42) in Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Study of Cerebrospinal Fluid Tissue Transglutaminase , T - TAU , Amyloid Β 42 in Alzheimer ’ s Disease
Biochemical markers for Alzheimer disease would be of great value, especially to help in early diagnosis of the disease. The current study has focused on three candidates that have been suggested to be indulged in the pathogenesis of Alzheimer’ disease (AD): Tissue transglutaminase (tTG) activity, β-amyloid42 (Aβ 42) and total T-tau (T-tau). The study included 15 patients with probable AD, 15 p...
متن کاملCerebrospinal Fluid β-Amyloid1–42 Levels in the Differential Diagnosis of Alzheimer’s Disease—Systematic Review and Meta-Analysis
OBJECTIVES The purpose of this study was to carry out systematic review of the literature and meta-analysis to evaluate the diagnostic utility of cerebrospinal fluid (CSF) levels of the 42 amino acid form of amyloid-beta (Aβ1-42) as a biomarker for differentiating Alzheimer's disease (AD) from non-AD dementia. METHODS Design. Systematic literature review was used to evaluate the effectiveness...
متن کاملPreanalytical variables and Alzheimer disease biomarker concentrations in cerebrospinal fluid.
Cerebrospinal fluid (CSF) -amyloid (A 1–42) is one of the key biological forms of -amyloid protein in brain tissue that inversely reflects brain amyloid burden with reduced concentrations in Alzheimer disease (AD) (1 ). Reductions in CSF A 1–42 have been shown to occur years before symptom onset (2 ) and to have good positive predictive value for progression from mild cognitive impairment to cl...
متن کاملCerebrospinal fluid biomarkers in the evaluation of Alzheimer disease.
Alzheimer disease (AD), the most prevalent form of dementia in older adults, is a neurodegenerative disorder characterized by cerebral amyloid angiopathy, extracellular accumulation of amyloid -protein (A ) in senile plaques, and intracellular accumulation of hyperphosphorylated proteins in neurofibrillary tangles in cortical and limbic brain regions. As life expectancy increases, the number of...
متن کاملElevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease.
BACKGROUND We used a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). OBJECTIVE To assess CSF BACE1 activity in AD. DESIGN Case-control and longitudinal foll...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Neurology
سال: 1999
ISSN: 0003-9942
DOI: 10.1001/archneur.56.6.673